Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death
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چکیده
منابع مشابه
Leaky "feet" and sudden death.
Increases in intracellular Ca 2 are crucial signaling events in many cell types. The cardiac isoform of the (sarco)endoplasmic reticulum Ca release channel or ryanodine receptor (RyR2) is an important component of this signaling pathway in a wide variety of both excitable (nerve, smooth muscle, and heart) and nonexcitable (parotid, pancreas, and adrenal medulla) cells and is a critical componen...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2016
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1605216113